Kratom’s Effects on the Brain

The Kratom tree (Mitragyna speciosa), an evergreen of the coffee (Rubiaceae) family, is found throughout Southeast Asia. Its leaves have long been used as a source of traditional medicine in the countries of Thailand, Indonesia, Malaysia, Myanmar, and Papua New Guinea. 

How It Works

Until relatively recently, the mechanisms by which Kratom extracts worked were unknown, and the specifics of its preparation and usage were the exclusive domain of indigenous healers. But now that Kratom is entering the mainstream, science is helping us unlock its secrets and understand how it affects the brain on a molecular level.

The key to Kratom’s effectiveness lies in its unique blend of more than 40 alkaloid constituents, which act upon the brain’s neurotransmitter systems. The exact ratios of alkaloids vary based on the Kratom strain, batch, and supplier, but the primary alkaloid constituent is mitragynine, which is classified as an opioid agonist. Opiate agonists bind to the same brain receptors as traditional opiates such as heroin or morphine, while producing the same side-effects of pain relief and euphoria. But unlike the more dangerous drugs, Kratom doesn’t lead to addiction or cause negative physical side effects such as respiratory depression, constipation, and increasing dosage tolerance.


Due to its unique dose response curve, the specific Kratom effects of the particular strain on the brain depend a great deal on the dosage. Understanding the typical effects, which range from stimulation at low doses to sedation at high doses, can help you manage your expectations of how the product will affect you. It can also help you figure out the appropriate dose for your particular needs. (Keep in mind that the relationship between Kratom dosing and side effects can vary based on things like body composition and genetic makeup, so your results may differ slightly.)

  • Low dosage (0 to 4 grams) – Mitragynine is a relatively weak alkaloid, so large amounts are required to produce a narcotic effect. At low doses, Kratom actually produce stimulatory effects, such as increased energy and mild euphoria. Side effects typical of opiates are absent or barely noticeable. Low doses can interfere with sleep, so it’s best to avoid it later in the day.
  • Moderate dosage (4 to 6 grams) – A dose of Kratom in this range can produce a blend of stimulation and sedation, ideally resulting in a feeling of balanced well-being. Since more alkaloids are binding with receptors in the brain, opiate-like side effects are more noticeable, particularly at the higher end of the dosage scale.
  • High dosage (6 or more grams) – The flood of alkaloids to the brain’s opiate receptors will result in a potent opioidergic/analgesic/sedative effect, with little to no feeling of stimulation. This dosage can “trick” the brain into feeling like it has taken a more traditional opiate, without the physiological risks associated with such drugs.


One of the most commonly reported side effects of Kratom is exceptionally vivid and memorable dreams. This likely occurs because Kratom has a profound influence on neurochemistry, modulating an array of neurotransmitter systems and actually altering brainwaves. This results in particularly intense delta waves during the sleep cycle, which the brain interprets as vivid dream imagery. Some users even report an enhanced ability to engage in lucid dreaming. This effect varies based on strain and dose. Low doses, though more likely to interfere with your ability to fall asleep, will probably have no noticeable effect on your dreams. The higher the dose, the greater the likelihood of evocative and interesting dreams.

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Author: James McQuiston

Ph.D. in Political Science, Kent State University. I have been the editor at NeuFutur / since I was 15. Looking for new staff members all the time; email me if you are interested. Thanks!

2 thoughts on “Kratom’s Effects on the Brain”

  1. My son is in a psych ward right now because of this drug. He has been taking it over the past few years and his mind is completely gone. He has devolved into a life filled with paranoid delusions in which he believes inanimate objects are antagonizing him. I was forced to have him commited recently because he believed that a woman reading a book on tape was jumping from my speaker into my body and he said that he was going to stab her in the heart if she did not stop messing with him. He was brandishing a knife at the time. He buys the drug in the form of O.P.M.S. pills from local head shops. Very soon I will be putting a curse on the people who put this drug on the market. My mother will help me and the last people she cursed ended up dead or suffering. I hope that the people who distribute this drug die screaming and my curse will ensure that they do.

  2. to the lady talking about her son in the psychward, your son was doing more than just kratom lol… theres no correlation with kratom and thwas activities, what you described is more along the lines of K2

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